Hydrochloric Acid → HCID 18428670, compound

Participants

Reaction Steps

The ester from example 152 (5.22 g, 15.8 mmol) was dissolved in THF (60 mL), treated with aqueous lithium hydroxide (1 M, 63.1 mmol) and heated at reflux overnight. The reaction was neutralised with hydrochloric acid (2 M) and extracted with DCM. The organic extracts were dried (MgSO4) and evaporated to a white foam of the title carboxylic acid (4.80 g, 95%); δH (CD3OD, 400 MHz) 2.48 (3 H, s), 2.56 (6 H, s), 3.94 (2 H, s), 6.80 (1 H, d), 7.00 (2 H, d), 7.33 (2 H, d), 7.94 (1 H, d), 8.09 (1 H, s); MS m/z (ES+) 318 (MH+).

Provenance & Evidence