Potassium Carbonate → HCID 18428686, compound

Participants

Reaction Conditions

Reaction Steps

The bromide of Example 23 (2.0 g, 6 mmol) was mixed with copper powder (378 mg, 6 mmol) 1,2,3-triazole (ca. 5 g, excess), and potassium carbonate (828 mg, 6 mmol) were heated together at 160° C. for 48 h. After cooling to room temperature the reaction mixture was partitioned between sodium hydroxide (3 M) and ethyl acetate. The organic layer was separated and washed with sodium hydroxide (3 M) (3 x), water, and brine, before being dried (MgSO4) and evaporated. The resulting residue was purified by flash chromatography [SiO2; DCM/ MeOH/ 880 NH3 (97.5:2.5:0.25)] to afford, separately, the 1-substitiuted triazole derivative compound of Example 181 and the 2-substituted isomer compound of Example 182. The hydrochloride salt of each was precipitated by treatment with ethereal hydrochloric acid (1 M solution, excess).

Provenance & Evidence