HCID 18427827, compound → HCID 18427819, compound

Participants

Reaction Steps

A 317 mg (0.87 mmol) portion of 1-benzyl-3-[3-(tert-butoxycarbonylamino)-1,1-difluorocyclobutan-3-yl]pyrrolidine (Isomer F1) was dissolved in 20 ml of ethanol to which was subsequently added 350 mg of 10% palladium on carbon catalyst. The thus prepared mixture was stirred for 2 hours under irradiation of light and under a hydrogen pressure of 4 atmospheres. After removal of the catalyst by filtration, the solvent was evaporated under a reduced pressure to give 239 mg (quantitative) of the title compound. The thus obtained compound was used in the following reaction without purification.

Provenance & Evidence