HCID 18427814, compound → HCID 18427799, compound

Participants

Reaction Steps

A 145 mg (0.416 mmol) portion of 1-benzyl-3-[3-(tert-butoxycarbonylamino)-1-fluorocyclobutan-3-yl]pyrrolidine (Isomer A) was dissolved in 10 ml of ethanol to which was subsequently added 150 mg of 10% palladium on carbon catalyst. The thus prepared mixture was stirred for 1.5 hours under irradiation of light and under a hydrogen pressure of 3.5 atmospheres. After removal of the catalyst by filtration, the solvent was evaporated under a reduced pressure to give 117 mg (quantitative) of the title compound. The thus obtained compound was used in the following reaction without purification.

Provenance & Evidence