Benzene → HCID 53684219, compound

Participants

Reaction Steps

A solution of 6.4 g. (18 mMol) 4-[2-(benzenesulphonylamino)-ethyl]-phenoxyacetyl chloride and 25 ml. anhydrous benzene is added dropwise at 0° to 5° C., over the course of 2 hours, to a mixture of 5.4 g. (72 mMol) 1-hydroxy-2-aminopropane and 35 ml. water, a precipitate thereby forming slowly. After standing overnight at 20° C., the precipitate is filtered off with suction and the filter cake is washed with dilute aqueous sodium hydroxide solution and then with water and dried. After recrystallization from ethyl acetate, there are obtained 5.2 g. (74% of theory) of the desired product; m.p. 90°-91° C.

Provenance & Evidence