Ammonia → 1-(p-2-Isopropoxyethoxymethylphenoxy)-3-amino-propan-2-ol

Participants

Reaction Steps

A solution of 10 g. of 1-(p-2-isopropoxyethoxymethylphenoxy)-3-isopropylideneamino-propan-2-ol [obtainable by reacting 1-(p-2-isopropoxyethoxymethylphenoxy)-2,3-epoxypropane with ammonia to give 1-(p-2-isopropoxyethoxymethylphenoxy)-3-amino-propan-2-ol and subsequently reacting this with acetone] in 250 ml. of ethanol was hydrogenated on 0.5 g. of Raney nickel at 25° under 1 atmosphere of pressure until 1 equivalent of H2 had been absorbed. The mixture was filtered and the filtrate evaporated to give 1-(p-2-isopropoxyethoxymethyl-phenoxy)-3-isopropylamino-propan-2-ol, fumarate, m.p. 100°.

Provenance & Evidence