HCID 59909748, compound → HCID 59909811, compound

Participants

Reaction Steps

A solution of tert-butyl (3R)-3-[({[(Z)-1-amino-2-(propylsulfonyl)ethylidene]amino}oxy)carbonyl]-6-cyclohexylhexanoate (Preparation 95) (760 mg, 1.60 mmol) in xylene (15 ml) was heated at 130° C. for 28 hours. After cooling to room temperature the reaction mixture was purified by column chromatography on silica gel eluting with a gradient system of 100:0 (pentane:ethyl acetate) gradually changing to 70:30 (pentane:ethyl acetate) to afford the title compound as a yellow oil (400 mg).

Provenance & Evidence