反应详情

温度

60 °C

Ethyl 4-chloro-3-nitrobenzoate (20.00 g, 87 mmol) was dissolved in DMSO (50 mL) and cyclohexylamine (2.1 equiv. 21 mL, 183 mmol) was added and the mixture stirred at 60° C. for 5 h. After cooling to ambient temperature, the reaction mixture was added drop-wise with vigorous stirring to water (500 mL). After stirring for an additional 15 min, the precipitated solid was collected by filtration, washed with water and dried. The title compound (25.67 g, 100% yield) was obtained as a bright yellow solid.

1. temperatureAfter cooling to ambient temperature
2. additionthe reaction mixture was added drop-wise
3. stirringAfter stirring for an additional 15 min
4. filtrationthe precipitated solid was collected by filtration
5. washwashed with water
6. customdried