Methanol → HCID 18429320, compound

HRID 1280123Notes

Reaction equation

HRID 1280123 reaction equation
C([O:4][CH2:5][C:6]([NH:8][C:9]1[C:10]([I:30])=[C:11]([C:17]([I:29])=[C:18]([NH:21][C:22](=[O:28])[CH2:23][O:24]C(=O)C)[C:19]=1[I:20])[CH2:12]CC([O-])=O)=[O:7])(=O)C.C[OH:32]>[OH-].[Na+]>[OH:4][CH2:5][C:6]([NH:8][C:9]1[C:10]([I:30])=[C:11]([C:17]([I:29])=[C:18]([NH:21][C:22](=[O:28])[CH2:23][OH:24])[C:19]=1[I:20])[CH2:12][OH:32])=[O:7]

Participants

4

Reactant 2

HCID 887MethanolHCID 18429372HCID 18429372, compound

Product 1

HCID 18429320HCID 18429320, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

3,5-Bis(acetoxyacetylamino)-2,4,6-triiodobenzylacetate (152 mg, 0.2 mmol) was dissolved in a mixture of methanol (6 ml) and 1 M aqueous NaOH (2 ml) and the solution was stirred for 2 h at room temperature. After neutralization with 1 M HCl, the solvents were removed by evaporation and the product was purified by preparative HPLC. Yield: 105 mg (83%).

Workup

  1. customAfter neutralization with 1 M HCl, the solvents were removed by evaporation
  2. customthe product was purified by preparative HPLC

Sources & evidence

ORD record
ord-b952f4dcc34f4af68e046ce4b81d122a
Source dataset
uspto-grants-2002_09
Patent number
US06448442B1

Reaction notes

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