3',5'-Dinitroacetophenone → HCID 18429142, compound

HRID 1280140Notes

Reaction equation

HRID 1280140 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[CH:7]=[C:6]([N+:13]([O-])=O)[CH:5]=1)=[O:3]>CO.[Pd]>[NH2:10][C:8]1[CH:9]=[C:4]([CH:2]([OH:3])[CH3:1])[CH:5]=[C:6]([NH2:13])[CH:7]=1

Participants

4

Reactant 1

HCID 2585693',5'-Dinitroacetophenone

Product 1

HCID 18429142HCID 18429142, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

3,5-Dinitroacetophenone (2.02 g, 9.5 mmol) which had been prepared according to the literature procedure (Y. Nagase et al., Macromol. Chem. Rapid Comm. (1990) 11, 185-191) was dissolved in methanol (100 ml) and hydrogenated at 60 psi using a Pd/C catalyst (5%, 100 mg). The catalyst was filtered off and the solvent was removed by evaporation. The product was used without purification in the next step. Yield: 1.22 g (84%).

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was removed by evaporation
  3. customThe product was used without purification in the next step

Sources & evidence

ORD record
ord-1efb1d35067442099d83b54c1bf05efa
Source dataset
uspto-grants-2002_09
Patent number
US06448442B1

Reaction notes

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