3-(Methylamino)propane-1,2-diol → HCID 18429374, compound

HRID 1280161Notes

Reaction equation

HRID 1280161 reaction equation
[NH2:1][C:2]1[C:3]([I:18])=[C:4]([CH2:13][O:14][C:15](=[O:17])[CH3:16])[C:5]([I:12])=[C:6]([C:10]=1[I:11])[C:7](Cl)=[O:8].[CH3:19][NH:20][CH2:21][CH:22]([OH:25])[CH2:23][OH:24]>>[NH2:1][C:2]1[C:3]([I:18])=[C:4]([CH2:13][O:14][C:15](=[O:17])[CH3:16])[C:5]([I:12])=[C:6]([C:10]=1[I:11])[C:7]([N:20]([CH3:19])[CH2:21][CH:22]([OH:25])[CH2:23][OH:24])=[O:8]

Participants

3

Reactant 2

HCID 27341223-(Methylamino)propane-1,2-diolHCID 184293385-Amino-3-acetoxymethyl-2,4,6-triiodobenzoyl chloride

Product 1

HCID 18429374HCID 18429374, compoundYield 97%

Procedure

5-Amino-3-acetoxymethyl-2,4,6-triiodobenzoyl chloride was reacted with N-methyl-2,3-dihydroxypropylamine according to the conditions in Example 24g. The product was isolated in 97% yield.

Workup

  1. customThe product was isolated in 97% yield

Sources & evidence

ORD record
ord-26f245c3ad40477ca6087fc8f88ef89b
Source dataset
uspto-grants-2002_09
Patent number
US06448442B1

Reaction notes

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