Acetic Acid → HCID 18429138, compound

Participants

Reaction Steps

Benzyl 2-acetoxy-5-chloropentanoate (52.6 g, 0.19 mol) was dissolved in ethyl acetate (350 ml) and acetic acid (25 ml) and hydrogenated at 10 psi in a Parr apparatus in the presence of a Pd/C catalyst (5%, 2.5 g). After completion, the catalyst was filtered off and the volatiles were evaporated. The residue was dried in vacuo ( 1 mm Hg, 100° C.), and 35 g (98%) of the crude product was isolated and used without further purification.

Provenance & Evidence