HCID 18429216, compound → HCID 18429150, compound

HRID 1280183Notes

Reaction equation

[NH2:1][C:2]1[C:3]([I:34])=[C:4]([CH2:29][O:30][C:31](=[O:33])[CH3:32])[C:5]([I:28])=[C:6]([C:26]=1[I:27])[C:7]([NH:9][CH:10]([CH:16]([O:22][C:23](=[O:25])[CH3:24])[CH2:17][O:18][C:19](=[O:21])[CH3:20])[CH2:11][O:12][C:13](=[O:15])[CH3:14])=[O:8].[C:35]([O:38][CH:39]([CH:43]([O:49][C:50](=[O:52])[CH3:51])[CH2:44][O:45][C:46](=[O:48])[CH3:47])[C:40](Br)=[O:41])(=[O:37])[CH3:36]>>[C:35]([O:38][CH:39]([CH:43]([O:49][C:50](=[O:52])[CH3:51])[CH2:44][O:45][C:46](=[O:48])[CH3:47])[C:40]([NH:1][C:2]1[C:3]([I:34])=[C:4]([CH2:29][O:30][C:31](=[O:33])[CH3:32])[C:5]([I:28])=[C:6]([C:26]=1[I:27])[C:7]([NH:9][CH:10]([CH:16]([O:22][C:23](=[O:25])[CH3:24])[CH2:17][O:18][C:19](=[O:21])[CH3:20])[CH2:11][O:12][C:13](=[O:15])[CH3:14])=[O:8])=[O:41])(=[O:37])[CH3:36]

Participants

Reactant 2

HCID 18429216HCID 18429216, compound

HCID 18429217HCID 18429217, compound

Product 1

HCID 18429150HCID 18429150, compoundYield 45%

Procedure

5-Amino-3-acetoxymethyl-N-(1,3,4-triacetoxybut-2-yl)-2,4,6-triiodobenzamide (20 g, 24.5 mmol) was acylated with 2,3,4-triacetoxybutanoyl bromide (15.9 g, 49.0 mmol) according to the procedure given in example 80a. The yield was 45%.

Sources & evidence

ORD record: ord-9404abaa9416424b9b6bc718036551d1
Source dataset: uspto-grants-2002_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06448442B1

Reaction notes

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