Hydrochloric Acid → 5-(6-chloro-3-pyridinyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione dihydrochloride

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Reaction Steps

5-(6-chloro-3-pyridinyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione (E58, 31 mg, 0.06 mmol) was suspended in 1 ml of dioxane and 4M HCl in dioxane solution (31 μl, 0.12 mmol) was added. The mixture was stirred at room temperature for 5 minutes, and then the solvent was removed in vacuum to give 33 mg of the title compound as an off-white powder (94%, yield).

Provenance & Evidence