Ethanol → HCID 23471607, compound

Participants

Reaction Steps

A solution of 4.9 g of 4-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)carbonyl-γ-butyrolactone and 3.0 ml of 85% hydrazine hydrate in 50 ml of ethanol was heated under reflux overnight. The reaction mixture was concentrated under reduced pressure and ice-cold water was added to the residue. After the mixture was allowed to stand, the precipitated crystals were filtered off and recrystallized from water to give 2.5 g of 6-(5-hydroxymethyl-3-oxo-2,3,4,5-tetrahydropyridazin-6-yl)-1-methyl-1,2,4,5-tetrahydroquinolin-2-one as colorless prisms, melting at 201°-204° C.

Provenance & Evidence