反应详情

To 9.81 g of 40% aqueous chloroacetaldehyde solution was added 3.77 g of O-tert-butylhydroxylamine hydrochloride with stirring at room temperature. After stirring at room temperature for 2 hours, the reaction mixture was extracted twice with diethyl ether. The diethyl ether layers were combined, washed with water, dried over anhydrous magnesium sulfate, and concentrated, which afforded 4.21 g (yield, 94%) of chloroacetaldehyde O-tert-butyloxime, nD23.2 1.4418.

1. stirringAfter stirring at room temperature for 2 hours
2. extractionthe reaction mixture was extracted twice with diethyl ether
3. washwashed with water
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationconcentrated