反应详情

A solution of 12.3 g (0.05 mole) of 5-chloro-2-methylaminobenzophenone and 11.9 g (0.1 mole) of phenyl isocyanate in 50 ml of methylene chloride was refluxed for 3 days, and then evaporated to dryness under reduced pressure. The residual syrup was stirred with ether until it crystallized. The crystals were collected on a filter and washed with ether to give 12.06 g (66%) of 1-(2-benzoyl-4-chlorophenyl)-1-methyl-3-phenylurea as light yellow crystals. A sample was recrystallized from ethanol to give colorless crystals: mp 158°-160°; 1H nmr (DMSO-d6) δ3.41 ppm (s, 3H), 6.7-7.5 ppm (m, 13H).

1. customevaporated to dryness under reduced pressure
2. customcrystallized
3. customThe crystals were collected on
4. filtrationa filter
5. washwashed with ether