反应详情

Into 10 ml of boron trifluoride methanol complex, methanol solution was added 0.25 g of methyl [2-(5-acetylamino-2-chloro-4-fluorophenoxy)phenoxy]acetate, and the mixture was heated for 3 hours while stirring. Thereafter, the reaction solution was concentrated, the residue was dissolved in ethyl acetate, and washed with saturated aqueous sodium bicarbonate, dried over magnesium sulfate, and concentrated to obtain 0.2 g of methyl [2-(5-amino-2-chloro-4-fluorophenoxy)phenoxy]acetate [Intermediate compound A3-22].

1. temperaturethe mixture was heated for 3 hours
2. concentrationThereafter, the reaction solution was concentrated
3. dissolutionthe residue was dissolved in ethyl acetate
4. washwashed with saturated aqueous sodium bicarbonate
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated