HCID 86584266, compound → HCID 86584267, compound

HRID 1280376Notes

Reaction equation

HRID 1280376 reaction equation
C([NH:4][C:5]1[C:6]([F:26])=[CH:7][C:8]([Cl:25])=[C:9]([CH:24]=1)[O:10][C:11]1[CH:23]=[CH:22][CH:21]=[CH:20][C:12]=1[O:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])(=O)C>CO>[NH2:4][C:5]1[C:6]([F:26])=[CH:7][C:8]([Cl:25])=[C:9]([CH:24]=1)[O:10][C:11]1[CH:23]=[CH:22][CH:21]=[CH:20][C:12]=1[O:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16]

Participants

3

Reactant 1

HCID 86584266HCID 86584266, compound

Product 1

HCID 86584267HCID 86584267, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Into a boron trifluoride methanol complex, methanol solution is added ethyl [2-(5-acetylamino-2-chloro-4-fluorophenoxy)phenoxy]acetate, and the mixture is heated while stirring. Thereafter, the reaction solution is concentrated, the residue is dissolved in ethyl acetate, and washed with saturated aqueous sodium bicarbonate, dried over magnesium sulfate, and concentrated to obtain ethyl [2-(5-amino-2-chloro-4-fluorophenoxy)phenoxy]acetate [Intermediate compound A3-23].

Workup

  1. temperaturethe mixture is heated
  2. concentrationThereafter, the reaction solution is concentrated
  3. dissolutionthe residue is dissolved in ethyl acetate
  4. washwashed with saturated aqueous sodium bicarbonate
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-ad8a1b0fe0214050aad2e53579df7c54
Source dataset
uspto-grants-2002_09
Patent number
US06451740B2

Reaction notes

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