反应详情

Into a boron trifluoride methanol complex, methanol solution is added ethyl [2-(5-acetylamino-2-chloro-4-fluorophenoxy)phenoxy]acetate, and the mixture is heated while stirring. Thereafter, the reaction solution is concentrated, the residue is dissolved in ethyl acetate, and washed with saturated aqueous sodium bicarbonate, dried over magnesium sulfate, and concentrated to obtain ethyl [2-(5-amino-2-chloro-4-fluorophenoxy)phenoxy]acetate [Intermediate compound A3-23].

1. temperaturethe mixture is heated
2. concentrationThereafter, the reaction solution is concentrated
3. dissolutionthe residue is dissolved in ethyl acetate
4. washwashed with saturated aqueous sodium bicarbonate
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated