Epibromohydrin → 2-(Oxiran-2-ylmethoxy)indane

Participants

Reaction Steps

To a solution of 60% NaH (0.18 g, 4.5 mmol) in DMF (10 ml) cooled to 0 degrees was added 2-indanol (0.5 g, 3,73 mmol) in DMF (2 ml) dropwise. After stirring for 30 minutes epibromohydrin (1.11 g, 8.18 mmol) in DMF (1 ml) was added dropwise. The reaction was allowed to warm to room temperature and stirred for 48 h. The solvent was removed in vacuo and the residue was purified using Prep TLC (30:1, DCM:MeOH) to afford compound 6.

Provenance & Evidence