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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1280424Generated: October 31, 2026

4-Methylbenzyl alcohol → N-(2,6-dimethylphenyl)-2-(4-{2-hydroxy-3-[(4-methylphenyl)methoxy]propyl}piperazinyl)acetamide

https://huagongshe.com/reaction/1280424

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methylbenzyl alcoholHCID 11505—
ReactantN-(2,6-dimethylphenyl)-2-[4-(2-hydroxy-3-indan-2-yloxypropyl)piperazinyl]acetamideHCID 10181578—
SolventIsopropanolHCID 3776—
ProductN-(2,6-dimethylphenyl)-2-(4-{2-hydroxy-3-[(4-methylphenyl)methoxy]propyl}piperazinyl)acetamideHCID 10113203—

Reaction Steps

Compound 22 was prepared in a similar manner to compound 7, substituting the commercially available 4-methyl-benzylalcohol for 2-propanol in part C. MS (M+1)=426.41

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06451798B2
Source datasetuspto-grants-2002_09
ORD IDord-eabc753d759a4273818942d600c9ba48
Source noteuspto-grants-2002_09