Acetic Acid → HCID 12018226, compound

Participants

Reaction Steps

0.6 g (1.97 mmol) of 1-benzyl-3-(5-formyl-2-furyl)pyrazolo[3,4-d]pyrimidine (Rf=0.65, SiO2, ethyl acetate) is treated with 60 mg of NaBH4 with good stirring in 20 ml of 1-propanol at room temperature. After 15 min, 50 ml of water and 2.5 ml of glacial acetic acid are added. After partially concentrating in a rotary evaporator, the mixture is extracted with ethyl acetate, and the extract is dried and concentrated in a rotary evaporator after addition of toluene. After chromatography on SiO2, 74.8 mg (12.4% of theory) of product are obtained (m.p. 165° C., Rf=0.43, SiO2, ethyl acetate).

Provenance & Evidence