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1-(2-aminoethyl)-1H-imidazo[4,5-c]quinolin-4-amine → n1-[2-(4-Amino-1h-imidazo[4,5-c]quinolin-1-yl)ethyl]-5-(2-oxoperhydrothieno[3,4-d]imidazol-4-yl)pentanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(2-aminoethyl)-1H-imidazo[4,5-c]quinolin-4-amine | HCID 23512719 | — |
| 反応物 | N-Hydroxysuccinimido-d-biotin | HCID 129676281 | — |
| 生成物 | n1-[2-(4-Amino-1h-imidazo[4,5-c]quinolin-1-yl)ethyl]-5-(2-oxoperhydrothieno[3,4-d]imidazol-4-yl)pentanamide | HCID 23512652 | 75.2% |
反応手順
Using the general method of Example 24, N-hydroxysuccinimidobiotin (0.6 g, 1.76 mmol) was reacted with 1-(2-aminoethyl)-1H-imidazo[4,5-c]quinolin-4-amine (0.4 g, 1.76 mmol) to provide 0.6 g of N1-[2-(4-amino-1H-imidazo[4,5-c]quinolin-1-yl)ethyl]-5-(2-oxoperhydrothieno[3,4-d]imidazol-4-yl)pentanamide as a solid, m.p. 169° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06451810B1 |
| 出典データセット | uspto-grants-2002_09 |
| ORD ID | ord-a9d6237504f2476893d24b6538b61c58 |
| 出典メモ | uspto-grants-2002_09 |