HCID 18425515, compound → HCID 178517126, compound

Participants

Reaction Conditions

Reaction Steps

7-Benzylsulfonyl-3-(2-chlorophenyl)-1-(2,2,2-trifluoroethyl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (300 mg, 0.604 mmol), trans-4-aminocyclohexanol (208 mg, 3 equivalents) and 1-methyl-2-pyrrolidinone (0.3 mL) were heated with stirring at 110° C. for 20 minutes, at which time it was cooled to room temperature. The residue was purified using preparative thin layer chromatography using ethyl acetate as eluant, to give 155 mg of 3-(2-chlorophenyl)-7-(trans4-hydroxycyclohexylamino)-1-(2,2,2-trifluoroethyl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one as an off-white powder.

Provenance & Evidence