HCID 18425441, compound → [1-(2,2,2-trifluoroethyl)piperidin-4-yl]methanamine

HRID 1280572Notes

Reaction equation

HRID 1280572 reaction equation
C(O[NH:9][CH2:10][CH:11]1[CH2:16][CH2:15][N:14]([CH2:17][C:18]([F:21])([F:20])[F:19])[CH2:13][CH2:12]1)C1C=CC=CC=1>C(O)C.[Pd]>[NH2:9][CH2:10][CH:11]1[CH2:16][CH2:15][N:14]([CH2:17][C:18]([F:21])([F:19])[F:20])[CH2:13][CH2:12]1

Participants

4

Reactant 1

HCID 18425441HCID 18425441, compound

Product 1

HCID 18425514[1-(2,2,2-trifluoroethyl)piperidin-4-yl]methanamine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

4-Benzyloxyaminomethyl-1-(2,2,2-trifluoroethyl)piperidine was dissolved in ethanol (50 mL) and hydrogenated over 10% palladium on carbon (0.5 g) for 10 hours. The mixture was filtered through a pad of celite and washed with methanol. The filtrate was evaporated to give 1.17 g of 4-aminomethyl-1-(2,2,2-trifluoroethyl)piperidine as a semi-solid.

Workup

  1. filtrationThe mixture was filtered through a pad of celite
  2. washwashed with methanol
  3. customThe filtrate was evaporated

Sources & evidence

ORD record
ord-b7b17105a05f4e978f7d04e8abdb8dc1
Source dataset
uspto-grants-2002_09
Patent number
US06451804B1

Reaction notes

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