Hydrochloric Acid → HCID 178505150, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the 3-(2-chlorophenyl)-7-[trans-4-(methanesulfonylamino)cyclohexylamino]-1-[2-(trimethylsilyl)ethoxymethyl]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (290 mg, 0.5 mmol) in 5 mL methanol was added 4.0 mL of 10% aqueous hydrochloric acid. The reaction mixture was stirred at 40° C. for 24 hours, and was concentrated in vacuo. Repeated triturations of the colorless. oil with ethyl acetate gave 3-(2-chlorophenyl)-7-[trans-4-(methanesulfonylamino)cyclohexylamino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one a white solid which was collected by vacuum filtration.

Provenance & Evidence