Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → N-(1-methoxy-1-ethyl)-2'-methyl-6'-ethyl-2-chloroacetanilide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | 2-Chloroethyl methyl ether | HCID 12316 | — |
| 반응물 | 2-Chloro-N-(2-ethyl-6-methylphenyl)acetamide | HCID 670477 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | N-(1-methoxy-1-ethyl)-2'-methyl-6'-ethyl-2-chloroacetanilide | HCID 20034188 | 86% |
반응 단계
The same general procedure of Example 32 was followed, except here the sec-amide, 2'-methyl-6'-ethyl-2-chloroacetanilide, 21.1 g (0.1 mol), was solubilized with a small amount of THF in 400-500 ml diethyl ether. Reaction went well, but gas evolved when chloroethyl methyl ether was added. However, at final addition (about 2.5×theory) the added ether didn't react although some KH was still present. Upon workup, the product, N-(1-methoxy-1-ethyl)-2'-methyl-6'-ethyl-2-chloroacetanilide, was obtained in 86% yield, b.p. 130° at 0.05 mm Hg.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04258196 |
| 출처 데이터셋 | uspto-grants-1981_03 |
| ORD ID | ord-bfc6523af2e946e684a67af53e1a2d6e |
| 출처 메모 | uspto-grants-1981_03 |