Hydrochloric Acid → (-)-(4S)-4-cyclohexylmethyl-4,5-dihydro-1,3-thiazol-2-ylamine

Participants

Reaction Conditions

Reaction Steps

The process is performed as in Example 1, starting with 11.1 g of N-(tert-butyl)-N′-[(1S)-1-cyclohexylmethyl-2-hydroxyethyl]thiourea in 110 cm3 of aqueous 6N hydrochloric acid maintained at a temperature in the region of 100° C. for 2 hours. By means of an identical work-up, 3.6 g of (−)-(4S)-4-cyclohexylmethyl-4,5-dihydro-1,3-thiazol-2-ylamine are obtained in the form of a white solid melting at 169° C. (αD20=−33.9±0.8 at a concentration of 0.5% in methanol).

Provenance & Evidence