反应详情

温度

20 °C

A solution of 12.5 g of (2R)-2-amino-5-[(benzyloxy)carbonyl]aminopentanoic acid hydrochloride in 200 cm3 of ethanol is cooled to a temperature in the region of −20° C. 6.5 cm3 of thionyl chloride are added dropwise and the mixture is then stirred at a temperature in the region of 20° C. for 18 hours. The reaction medium is concentrated under reduced pressure (1 kPa) at a temperature in the region of 40° C. to give 13 g of ethyl (2R)-2-amino-5-[(benzoyloxy)carbonyl]aminopentanoate hydrochloride [mass spectrum: DCI m/z=295 MH+].

1. concentrationThe reaction medium is concentrated under reduced pressure (1 kPa) at a temperature in the region of 40° C.