4-Phenylbutanal → HCID 10131437, compound

HRID 1280696Notes

Reaction equation

HRID 1280696 reaction equation
FC(F)(F)C(O)=O.[NH:8]1[CH2:12][CH2:11][C@@H:10]([S:13][C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=2)[CH2:9]1.[C:21]1([CH2:27][CH2:28][CH2:29][CH:30]=O)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C(Cl)(Cl)Cl>[C:21]1([CH2:27][CH2:28][CH2:29][CH2:30][N:8]2[CH2:12][CH2:11][C@@H:10]([S:13][C:14]3[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=3)[CH2:9]2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 2

HCID 290304-PhenylbutanalHCID 69924259HCID 69924259, compound

Product 1

HCID 10131437HCID 10131437, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound, MS: m/e=328.3 (M+H+) and [α]D20 +10.15° (c=0.56, chloroform) was prepared from (R)-4-(pyrrolidin-3-yl-sulfanyl)-phenol trifluoroacetic acid salt and 4-phenyl-butyraldehyde.

Sources & evidence

ORD record
ord-c3821cf98b374359aae7b088dcafbefb
Source dataset
uspto-grants-2002_09
Patent number
US06451819B2

Reaction notes

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