4-Phenylbutanal → (RS)-5-[1-(4-Phenyl-butyl)-pyrrolidine-3-sulfonyl]-1H-indazole

HRID 1280701Notes

Reaction equation

HRID 1280701 reaction equation
FC(F)(F)C(O)=O.[NH:8]1[CH2:12][CH2:11][CH:10]([S:13]([C:16]2[CH:17]=[C:18]3[C:22](=[CH:23][CH:24]=2)[NH:21][N:20]=[CH:19]3)(=[O:15])=[O:14])[CH2:9]1.[C:25]1([CH2:31][CH2:32][CH2:33][CH:34]=O)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[C:25]1([CH2:31][CH2:32][CH2:33][CH2:34][N:8]2[CH2:12][CH2:11][CH:10]([S:13]([C:16]3[CH:17]=[C:18]4[C:22](=[CH:23][CH:24]=3)[NH:21][N:20]=[CH:19]4)(=[O:15])=[O:14])[CH2:9]2)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 290304-PhenylbutanalHCID 69923694(RS)-5-(pyrrolidine-3-sulfonyl)-1H-indazole trifluoroacetic acid

Product 1

HCID 18425797(RS)-5-[1-(4-Phenyl-butyl)-pyrrolidine-3-sulfonyl]-1H-indazole

Procedure

The title compound, MS: m/e=384.2(M+H+) was prepared from (RS)-5-(pyrrolidine-3-sulfonyl)-1H-indazole trifluoroacetic acid and 4-phenyl-butyraldehyde.

Sources & evidence

ORD record
ord-c983e7895a83423596614fb9a6090f2b
Source dataset
uspto-grants-2002_09
Patent number
US06451819B2

Reaction notes

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