4-Phenylbutanal → (RS)-6-[1-(4-Phenyl-butyl)-pyrrolidine-3-sulfonyl]-3H-benzooxazol-2-one

HRID 1280704Notes

Reaction equation

HRID 1280704 reaction equation
FC(F)(F)C(O)=O.[NH:8]1[CH2:12][CH2:11][CH:10]([S:13]([C:16]2[CH:25]=[CH:24][C:19]3[NH:20][C:21](=[O:23])[O:22][C:18]=3[CH:17]=2)(=[O:15])=[O:14])[CH2:9]1.[C:26]1([CH2:32][CH2:33][CH2:34][CH:35]=O)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[C:26]1([CH2:32][CH2:33][CH2:34][CH2:35][N:8]2[CH2:12][CH2:11][CH:10]([S:13]([C:16]3[CH:25]=[CH:24][C:19]4[NH:20][C:21](=[O:23])[O:22][C:18]=4[CH:17]=3)(=[O:15])=[O:14])[CH2:9]2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 290304-PhenylbutanalHCID 69926767HCID 69926767, compound

Product 1

HCID 18425857(RS)-6-[1-(4-Phenyl-butyl)-pyrrolidine-3-sulfonyl]-3H-benzooxazol-2-one

Procedure

The title compound, MS: m/e=401.4 (M+H+) was prepared from (RS)-6-(pyrrolidine-3-sulfonyl)-3H-benzooxazol-2-one trifluoroacetic acid and 4-phenyl-butyraldehyde.

Sources & evidence

ORD record
ord-bbda804f87c94b1999d8573ab8713a82
Source dataset
uspto-grants-2002_09
Patent number
US06451819B2

Reaction notes

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