Toluene-4-sulfonic acid 4-phenyl-but-3-ynyl ester → HCID 18425817, compound

HRID 1280712Notes

Reaction equation

HRID 1280712 reaction equation
FC(F)(F)C(O)=O.[NH:8]1[CH2:12][CH2:11][CH:10]([S:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=2)(=[O:15])=[O:14])[CH2:9]1.[C:23]1([C:29]#[C:30][CH2:31][CH2:32]OS(C2C=CC(C)=CC=2)(=O)=O)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[C:23]1([C:29]#[C:30][CH2:31][CH2:32][N:8]2[CH2:12][CH2:11][CH:10]([S:13]([C:16]3[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=3)(=[O:15])=[O:14])[CH2:9]2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 13125083Toluene-4-sulfonic acid 4-phenyl-but-3-ynyl esterHCID 18425771(RS)-4-(Pyrrolidine-3-sulfonyl)-phenol trifluoroacetic acid

Product 1

HCID 18425817HCID 18425817, compound

Procedure

The title compound, MS: m/e=355.1 (M+) was prepared from (RS)-4-(pyrrolidine-3-sulfonyl)-phenol trifluoroacetic acid salt and toluene-4-sulfonic acid 4-phenyl-but-3-ynyl ester.

Sources & evidence

ORD record
ord-1cc36456ac2346d6ac9fa4b9ea0f8caa
Source dataset
uspto-grants-2002_09
Patent number
US06451819B2

Reaction notes

Loading…