Cornforth reagent → HCID 69926974, compound

Participants

Reaction Steps

(3RS,4RS)-3-(4-Benzyloxy-benzenesulfonyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester (50 mg, 0.1 mmol) was dissolved in CH2Cl2 (2 ml) and treated successively with 4 Å molecular sieves (56 mg, powder) and pyridinium dichromate (56.4 mg, 0.15 mmol). After 3 hours stirring at room temperature, the reaction mixture was directly chromatographed over silica gel (hexane-ethyl acetate 4:1 then 1:1) to provide (RS)-3-(4-benzyloxy-benzenesulfonyl)-4-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester (27 mg, 48%) as an oil, MS: m/e=374.2 (M-tbutyl).

Provenance & Evidence