HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → N-[2-(1-diphenylmethylpiperidin-4-yl)-ethyl]-3-(pyridin-3-yl)-acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 3-(3-Pyridinyl)-2-propenoic acid | HCID 101984 | — |
| Reactant | 2-(1-Diphenylmethylpiperidine-4-yl)-ethylamine | HCID 18425741 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[2-(1-diphenylmethylpiperidin-4-yl)-ethyl]-3-(pyridin-3-yl)-acrylamide | HCID 53903109 | — |
Reaction Steps
Batch size: 2.3 g (15.5 mmol) 3-(3-pyridyl)-acrylic acid, 2.7 g (21.3 mmol) oxalyl chloride and 4.1 g (13.9 mmol) 2-(1-diphenylmethylpiperidine-4-yl)-ethylamine in 60 ml abs. dichlormethane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06451816B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-6ce95752464a46089733988d82bebf77 |
| Source note | uspto-grants-2002_09 |