HCID 13036368, compound → HCID 15917709, compound

HRID 128078Notes

Reaction equation

HRID 128078 reaction equation
N1(C2N=C3C=CC=CC=C3N=2)CCNCC1.[N:17]1[C:21]2=[CH:22][CH:23]=[CH:24][CH:25]=[CH:26][C:20]2=[N:19][C:18]=1[N:27]1[CH2:32][CH2:31][N:30]([C:33](=[NH:35])[NH2:34])[CH2:29][CH:28]1CC.N1C2=CC=CC=CC2=NC=1N1CCN(C(=N)N)CC1C.BrC1C=CC2C(=CC=1)N=C(N1CCN(C(=N)N)CC1)N=2.C(C1C=CC2C(=CC=1)N=C(N1CCN(C(=N)N)CC1)N=2)CC.C(OC1C=CC2C(=CC=1)N=C(N1CCN(C(=N)N)CC1)N=2)C.FC(F)(F)C1C=CC2C(=CC=1)N=C(N1CCN(C(=N)N)CC1)N=2>>[N:17]1[C:21]2=[CH:22][CH:23]=[CH:24][CH:25]=[CH:26][C:20]2=[N:19][C:18]=1[N:27]1[CH2:28][CH2:29][N:30]([C:33](=[NH:34])[NH2:35])[CH2:31][CH2:32]1

Participants

8

Reactant 7

HCID 13036368HCID 13036368, compoundHCID 20284329HCID 20284329, compoundHCID 20284350HCID 20284350, compoundHCID 20284361HCID 20284361, compoundHCID 20284367HCID 20284367, compoundHCID 23471643HCID 23471643, compoundHCID 23471645HCID 23471645, compound

Product 1

HCID 15917709HCID 15917709, compound

Procedure

In the same manner but replacing 2-(1-piperazinyl)cycloheptimidazole with an equivalent amount of another compound of formula I described in Example 2, the following compounds of formula I are obtained, respectively: 4-(2-cycloheptimidazolyl)-3-ethyl-1-piperazinecarboximidamide, 4-(2-cycloheptimidazolyl)-3-methyl-1-piperazinecarboximidamide, 4-(6-bromo-2-cycloheptimidazolyl)-1-piperazinecarboximidamide, 4-(6-propyl-2-cycloheptimidazolyl)-1-piperazinecarboximidamide, 4-(6-ethoxy-2-cycloheptimidazolyl)-1-piperazinecarboximidamide, and 4-(6-trifluoromethyl-2-cycloheptimidazolyl)-1-piperazinecarboximidamide.

Workup

  1. customthe following compounds of formula I are obtained

Sources & evidence

ORD record
ord-faecd58e46c24760aa3b8a03a7e430a3
Source dataset
uspto-grants-1981_03
Patent number
US04258188

Reaction notes

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