Allyl bromide → HCID 20507740, compound

Participants

Reaction Steps

A mixture of 2-(1-piperazinyl)cycloheptimidazole (3.15 g, described in Example 2) and potassium carbonate (1.14 g) in dimethyl sulfoxide (10 ml) was stirred for 15 min and a solution of 2-propenyl bromide (1.18 g) in dimethyl sulfoxide was added. The reaction mixture was stirred for 2.5 hr and diluted with brine. The solution was extracted with ethyl acetate and the organic extract was dried and evaporated to give the title compound (1.8 g): mp 108°-111° C.; ir(CHCl3) 1600, 1565 and 1520 cm-1 ; uv max (MeOH) 263(ε29,965), 237(ε25,490) and 362 nm (ε21,620) and nmr(CDCl3)δ 2.6(4H,s), 3.0(2H,d), 4.05(4H,t), 5.15(2H,m), 5.75(1H,m) and 7.65(5H,m).

Provenance & Evidence