Sodium Carbonate → HCID 54291610, compound

Participants

Reaction Steps

[[2-Ethyl-1-(2-bromo-phenylmethyl)-1H-indol-4-yl]oxy]acetic acid tert-butyl ester (1.3 g) was combined with 4-fluoro-phenylboronic acid in 20 mL of n-propanol at room temperature. After 30 minutes, the slurry was treated with palladium acetate, triphenylphosphine and 2 mL of 2 M sodium carbonate solution. The mixture was heated at reflux for one hour, cooled to room temperature and diluted with water. After stirring for 1 hour, the mixture was extracted with ethyl acetate, which was washed, dried, filtered, and concentrated to afford 1.1 g of product.

Provenance & Evidence