Trifluoroacetic acid → HCID 9912131, compound

Participants

Reaction Steps

[[2-Ethyl-1-(2-(4-fluorophenyl)-phenylmethyl)-3-ureido-1H-indol-4-yl]oxy]acetic acid tert-butyl ester (0.4 g) was treated with 2 mL of trifluoroacetic acid at room temperature. After two hours the excess acid was removed under vacuum, 5 mL of 1N hydrochloric acid added, the mixture extracted with ethyl acetate, which was washed, dried, and concentrated. The residue was treated with 2 mL of 1 N hydrochloric acid and stirred for several hours. The resulting tan solid was isolated by filtration to afford 0.20 g of [[2-ethyl-1-(2-(4-fluorophenyl)-phenylmethyl)-3-ureido-1H-indol-4-yl]oxy]acetic acid. Mass spectrum: 461

Provenance & Evidence