Water → HCID 23445654, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure in Example 2, step 3 using 3-iodomethoxy-5-methylbenzaldehyde (2.24 g, 8.11 mmol), phenylboronic acid (1.09 g, 8.92 mmol), palladium(II) acetate (36.4 mg, 0.162 mmol) and barium hydroxide octahydrate (3.83 g, 12.2 mmol) in DME:H2O. Purification on Biotage KP-Sil eluting with 15% acetone/hexane gave 1.54 g (84%) of the title compound as a yellow oil. 1H NMR (DMSO-d6) δ 2.37 (s, 3H), 3.39 (s, 3H), 7.42-7.59 (m, 5H), 7.74-7.79 (m, 2H), 9.96 (s, 1H).

Provenance & Evidence