Sodium Hydroxide → HCID 23445637, compound

HRID 1280887Notes

Reaction equation

HRID 1280887 reaction equation
[CH3:1][O:2][C:3]1[C:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:7][C:6]([CH:15]=[O:16])=[CH:5][C:4]=1[CH3:17].[OH-:18].[Na+]>[Ag-]=O>[CH3:1][O:2][C:3]1[C:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:7][C:6]([C:15]([OH:18])=[O:16])=[CH:5][C:4]=1[CH3:17]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 23445654HCID 23445654, compound

Product 1

HCID 23445637HCID 23445637, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 178418778HCID 178418778, compoundCatalyst

Procedure

The title compound was prepared according to the procedure in Example 6, step 3 using 6-methoxy-5-methyl-biphenyl-3-carbaldehyde (1.53 g, 6.77 mmol), silver (I) oxide (1.56 g, 6.77 mmol) and NaOH (2.71 g, 67.7 mmol) to give 1.46 g (89%) of the title compound as a white solid, mp 165-168° C. 1H NMR (DMSO-d6) δ 2.34 (s, 3H), 3.36 (s, 3H), 7.38-7.55 (m, 5H), 7.71 (d, 1H), 7.81 (dd, 1H). IR (KBr) 3400, 2950, 1700, 1600 and 1410 cm−1. mass spectrum (EI), m/z 242 (M+). Anal. Calcd. for C15H14O3.0.2H2O: C, 73.27; H, 5.91; N, 0.00. Found: C, 73.21; H, 5.93; N, 0.17.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-0965f99d32464d6f8333d2d105895cdc
Source dataset
uspto-grants-2002_09
Patent number
US06451845B1

Reaction notes

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