HCID 21193478, compound → HCID 23445653, compound

Participants

Reaction Steps

The tide compound was prepared according to the procedure in Example 5, step 3 using (2-benzyl-4,5-dimethyl-furan-3-yl)-(3-cyclopentyl-4-methoxy-phenyl)-methanone (17.7 g, 45.5 mmol) and 1M boron tribromide/CH2Cl2 (34.8 mL) in CH2Cl2. Purification on Biotage KP-Sil eluting with a 2, 5 & 10% EtOAc/pet. ether step gradient gave 6.15 g (36%) of the title compound. 1H NMR (DMSO-d6) δ 1.40-1.46 (m, 2H), 1.59-1.72 (m, 4H), 1.78 (s, 3H), 1.90-1.94 (m, 2H), 2.16 (s, 3H), 3.18 (quintet, 1H), 3.81 (s, 2H), 6.87 (d, 1H), 7.06 (d, 2H), 7.16-7.25 (m, 3H), 7.46 (dd, 1H), 7.55 (s, 1H), 10.33 (s, 1H).

Provenance & Evidence