HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron tribromide dichloromethane → (2-Benzyl-4,5-dimethyl-thiophen-3-yl)-(3-cyclopentyl-4-hydroxy-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron tribromide dichloromethane | HCID 22277759 | — |
| Reactant | HCID 23445655 | HCID 23445655 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2-Benzyl-4,5-dimethyl-thiophen-3-yl)-(3-cyclopentyl-4-hydroxy-phenyl)-methanone | HCID 23445667 | 19.7% |
Reaction Steps
The title compound was prepared according to the procedure in Example 5, step 3 using (2-benzyl-4,5-dimethyl-thiophen-3-yl)-(3-cyclopentyl-4-methoxy-phenyl)-methanone (3.32 g, 8.20 mmol) and 1M boron tribromide/CH2Cl2 (1.6 mL) in CH2Cl2. Purification on Biotage KP-Sil eluting with a 2, 5 & 10% EtOAc/hexane step gradient gave 0.63 g (18%) of the title compound. 1H NMR (DMSO-d6) δ consistent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06451845B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-5f6de0b31827496aab33d2ce4d38352d |
| Source note | uspto-grants-2002_09 |