Lithium amide → HCID 22664401, compound

HRID 1281070Notes

Reaction equation

HRID 1281070 reaction equation
[Cl:1][C:2]1[CH:33]=[CH:32][C:5]2=[N:6][N:7]([C:9]3[CH:10]=[C:11]([CH:18]=[C:19]([C:22]([C:25]4[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=4)([CH3:24])[CH3:23])[C:20]=3[OH:21])[CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])[N:8]=[C:4]2[CH:3]=1.[NH2-].[Li+]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:33]=[CH:32][C:5]2=[N:6][N:7]([C:9]3[CH:10]=[C:11]([CH:18]=[C:19]([C:22]([C:25]4[CH:26]=[CH:27][C:28]([Cl:31])=[CH:29][CH:30]=4)([CH3:23])[CH3:24])[C:20]=3[OH:21])[CH2:12][CH2:13][C:14]([O:16][CH2:17][CH2:11][CH2:10][CH2:9][CH2:20][CH2:19][CH2:22][CH3:23])=[O:15])[N:8]=[C:4]2[CH:3]=1

Participants

4

Reactant 2

HCID 24532Lithium amideHCID 22664402HCID 22664402, compound

Product 1

HCID 22664401HCID 22664401, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The compound prepared in Example 47 is refluxed in toluene in the presence of lithium amide and EXXAL® 8 (mixture of octanols, Exxon-Mobil) for four hours. The title compound is obtained.

Sources & evidence

ORD record
ord-ea150781a09b4e8da76548eef2caebf0
Source dataset
uspto-grants-2002_09
Patent number
US06451887B1

Reaction notes

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