Water → HCID 18426803, compound

Participants

Reaction Steps

To a solution of 5,6-dichloro-2-(4-formylphenyl)benzimidazole (291 mg, 1.00 mmol) in tetrahydrofuran (40 mL) were added potassium cyanide (260 mg, 4.00 mmol), sodium hydrogen sulfite (500 mg), and water (10 mL). The mixture was stirred at room temperature for 12 h. Water was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried on anhydrous sodium sulfate. The solvent was removed under reduced pressure to afford 2-[4-[cyano(hydroxy)methyl]phenyl]-5,6-dichlorobenzimidazole (278 mg, 87%).

Provenance & Evidence