Sodium Hydroxide → HCID 178518433, compound

Participants

Reaction Steps

To a suspension of 5,6-dichloro-2-[5-[(2,4-dioxothiazolidin-5-ylidene)methyl]-1-(4-methylphenyl)sulfonylindol-2-yl]benzimidazole (77 mg, 0.13 mmol) in methanol (5 mL) was added aqueous sodium hydroxide (2 mol/L; 1 mL), and the mixture was heated to reflux for 19 h. The reaction mixture was cooled on an ice bath, and pH was adjusted to 7. The precipitated products were collected by filtration followed by trituration with tetrahydrofuran/ethyl acetate to afford 5,6-dichloro-2-[5-[(2,4-dioxothiazolidin-5-ylidene)methyl]indol-2-yl]benzimidazole (10 mg, 18%).

Provenance & Evidence