Water → HCID 18426846, compound

Participants

Reaction Steps

To a solution of 5,6-dichloro-2-[5-formylindol-2-yl]-1-(methoxymethyl)benzimidazole obtained in Example 47 (32 mg, 0.086 mmol) in dimethylformamide (2 mL) were added iodomethane (0.027 mL, 0.43 mmol) and potassium tert-butoxide (19 mg, 0.17 mmol) under nitrogen atmosphere, and the mixture was stirred at room temperature for 18 h. Water was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, dried on anhydrous sodium sulfate. The solvent was removed under reduced pressure to afford 5,6-dichloro-2-[5-formyl-1-methylindol-2-yl]-1-methoxymethylbenzimidazole (30 mg, 90%).

Provenance & Evidence