Hydrochloric Acid → HCID 73176434, compound

Participants

Reaction Steps

To a solution of 5,6-dichloro-2-[5-[(2,4-dioxothiazolidin-5-ylidene)methyl]-1-methylindol-2-yl]-1-(methoxymethyl)benzimidazole obtained in Example 48 (26 mg, 0.053 mmol) in 1,4-dioxane (5 mL) was added concentrated hydrochloric acid (0.5 mL), and the mixture was heated to reflux for 1 h. The pH was adjusted to 7 by 2 mol/L sodium hydroxide and the precipitated products were collected by filtration to afford 5,6-dichloro-2-[5-[(2,4-dioxothiazolidin-5-ylidene)methyl]-1-methylindol-2-yl]benzimidazole (12 mg, 51%).

Provenance & Evidence