Potassium Hydroxide → HCID 15523873, compound

HRID 1281166Notes

Reaction equation

HRID 1281166 reaction equation
CS([N:5]1[C:13]2[C:8]([CH2:9][C:10]3[CH2:15][CH:14]([C:16]#[N:17])[C:11]=3[CH:12]=2)=[CH:7][CH2:6]1)(=O)=O.[OH-].[K+]>CO>[NH:5]1[C:13]2[C:8](=[CH:9][C:10]3[CH2:15][CH:14]([C:16]#[N:17])[C:11]=3[CH:12]=2)[CH:7]=[CH:6]1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 88183275HCID 88183275, compound

Product 1

HCID 15523873HCID 15523873, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.6 g of the product obtained in Step 3 are introduced into a solution of 7.7 g of potassium hydroxide in 190 ml of methanol. After 12 hours at reflux, the methanol is evaporated off and the residue is taken up in ether. After washing, the organic phase is dried and concentrated to yield the expected product.

Workup

  1. temperatureAfter 12 hours at reflux
  2. customthe methanol is evaporated off
  3. washAfter washing
  4. customthe organic phase is dried
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-54d6f5a3652141f387bea72df1e3ab2f
Source dataset
uspto-grants-2002_09
Patent number
US06452015B2

Reaction notes

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