Hydrochloric Acid → HCID 23382088, compound

Participants

Reaction Steps

850 ml of a 4M solution of hydrogen chloride in dioxane is added to a solution of 57 g (124.8 mmol) of 1-[p-(N,N-diethylamino)phenyl]-4(S)-hydroxy-2-(tert-butyloxycarbonyl)-amino-5(S)-amino-6-phenyl-2-azahexane (Example 2d) in 200 ml of DMF and the whole is stirred at RT for 4 h. After that, the mixture is concentrated and treated firstly with dioxane and then with toluene with subsequent evaporation taking place in each case. The residue is triturated twice with dioxane and decanted off. The oily title compound which is obtained in this way is subjected to further processing without any additional purification.

Provenance & Evidence